Also called Prograf, tacrolimus is difficult to dose. If too little of the drug is given, the body may reject the transplanted organ. Too much can cause serious side effects such as diabetes and skin cancer.
Different transplant patients need different doses of Prograf. Kelly Birdwell, M.D., M.S.C.I., and colleagues at Vanderbilt have discovered that a single genetic variation affects dose amounts.
The other drugs in PREDICT are:
Since it was launched in 2010, PREDICT has genotyped more than 14,000 Vanderbilt patients for 184 genetic variations that affect the body’s response to various drugs.
More than 12,000 of the patients, 88%, have genetic variations that increase their risk of adverse effects from one or more of these 5 drugs.
PREDICT is designed to protect these patients from getting the wrong dose of these drugs. Long-term, it will save lives, reduce health care costs and shorten hospital stays.