Vanderbilt Endocrinology

Kevin D. Niswender, M.D., Ph.D.
Associate Professor of Medicine
Assistant Professor of Molecular Physiology and Biophysics
kevin.d.niswender@vanderbilt.edu
Click here to view bio.

Research Specialty:
Diabetes, Endocrinology, Metabolism

Publications

Pendergast, JS, Niswender, KD, Yamazaki, S. Tissue-specific function of Period3 in circadian rhythmicity. PLoS One, 7(1), e30254, 2012

Hagan, S, Niswender, KD. Neuroendocrine regulation of food intake. Pediatr Blood Cancer, 58(1), 149-53, 2012

Silver, HJ, Niswender, KD, Keil, CD, Jiang, L, Feng, Q, Chiu, S, Krauss, RM, Wilke, RA. CNR1 Genotype Influences HDL-Cholesterol Response to Change in Dietary Fat Intake. PLoS One, 7(5), e36166, 2012

Niswender, KD. Basal insulin: beyond glycemia. Postgrad Med, 123(4), 27-37, 2011

Niswender, KD. Basal insulin: physiology, pharmacology, and clinical implications. Postgrad Med, 123(4), 17-26, 2011

Speed, N, Saunders, C, Davis, AR, Owens, WA, Matthies, HJ, Saadat, S, Kennedy, JP, Vaughan, RA, Neve, RL, Lindsley, CW, Russo, SJ, Daws, LC, Niswender, KD, Galli, A. Impaired striatal Akt signaling disrupts dopamine homeostasis and increases feeding. PLoS One, 6(9), e25169, 2011

Silver, HJ, Dietrich, MS, Niswender, KD. Effects of grapefruit, grapefruit juice and water preloads on energy balance, weight loss, body composition, and cardiometabolic risk in free-living obese adults. Nutr Metab (Lond), 8(1), 8, 2011

Niswender, KD, Daws, LC, Avison, MJ, Galli, A. Insulin regulation of monoamine signaling: pathway to obesity. Neuropsychopharmacology, 36(1), 359-60, 2011

Siuta, MA, Robertson, SD, Kocalis, H, Saunders, C, Gresch, PJ, Khatri, V, Shiota, C, Kennedy, JP, Lindsley, CW, Daws, LC, Polley, DB, Veenstra-Vanderweele, J, Stanwood, GD, Magnuson, MA, Niswender, KD, Galli, A. Dysregulation of the norepinephrine transporter sustains cortical hypodopaminergia and schizophrenia-like behaviors in neuronal rictor null mice. PLoS Biol, 8(6), e1000393, 2010

Silver, HJ, Welch, EB, Avison, MJ, Niswender, KD. Imaging body composition in obesity and weight loss: challenges and opportunities. Diabetes Metab Syndr Obes, 3, 337-47, 2010

Posey, KA, Clegg, DJ, Printz, RL, Byun, J, Morton, GJ, Vivekanandan-Giri, A, Pennathur, S, Baskin, DG, Heinecke, JW, Woods, SC, Schwartz, MW, Niswender, KD. Hypothalamic proinflammatory lipid accumulation, inflammation, and insulin resistance in rats fed a high-fat diet. Am J Physiol Endocrinol Metab, 296(5), E1003-12, 2009

Robinson, JR, Niswender, KD. What are the risks and the benefits of current and emerging weight-loss medications. Curr Diab Rep, 9(5), 368-75, 2009

Stafford, JM, Yu, F, Printz, R, Hasty, AH, Swift, LL, Niswender, KD. Central nervous system neuropeptide Y signaling modulates VLDL triglyceride secretion. Diabetes, 57(6), 1482-90, 2008

Huizinga, MM, Niswender, KD, Gebretsadik, T, Rothman, RL, Shintani, AK, Elasy, TA. Insulin Use and Weight Maintenance in Well-controlled Type 2 Diabetes: A Prospective Cohort Study. Obesity (Silver Spring), 16(8), 1933-1937, 2008

Niswender, KD, Beech, BM. Obesity: increasing awareness of novel environmental factors. Diabetes, 57(7), 1786-7, 2008

Niswender, KD, Magnuson, MA. Obesity and the beta cell: lessons from leptin. J Clin Invest, 117(10), 2753-6, 2007

Saraswathi, V, Gao, L, Morrow, JD, Chait, A, Niswender, KD, Hasty, AH. Fish oil increases cholesterol storage in white adipose tissue with concomitant decreases in inflammation, hepatic steatosis, and atherosclerosis in mice. J Nutr, 137(7), 1776-82, 2007

Gelling, RW, Morton, GJ, Morrison, CD, Niswender, KD, Myers, MG, Rhodes, CJ, Schwartz, MW. Insulin action in the brain contributes to glucose lowering during insulin treatment of diabetes. Cell Metab, 3(1), 67-73, 2006

Morton, GJ, Gelling, RW, Niswender, KD, Morrison, CD, Rhodes, CJ, Schwartz, MW. Leptin regulates insulin sensitivity via phosphatidylinositol-3-OH kinase signaling in mediobasal hypothalamic neurons. Cell Metab, 2(6), 411-20, 2005

Morton, GJ, Blevins, JE, Williams, DL, Niswender, KD, Gelling, RW, Rhodes, CJ, Baskin, DG, Schwartz, MW. Leptin action in the forebrain regulates the hindbrain response to satiety signals. J Clin Invest, 115(3), 703-10, 2005

Morrison, CD, Morton, GJ, Niswender, KD, Gelling, RW, Schwartz, MW. Leptin inhibits hypothalamic Npy and Agrp gene expression via a mechanism that requires phosphatidylinositol 3-OH-kinase signaling. Am J Physiol Endocrinol Metab, 289(6), E1051-7, 2005

Schwartz, MW, Niswender, KD. Adiposity signaling and biological defense against weight gain: absence of protection or central hormone resistance. J Clin Endocrinol Metab, 89(12), 5889-97, 2004

Niswender, KD, Baskin, DG, Schwartz, MW. Insulin and its evolving partnership with leptin in the hypothalamic control of energy homeostasis. Trends Endocrinol Metab, 15(8), 362-9, 2004

Niswender, KD, Morrison, CD, Clegg, DJ, Olson, R, Baskin, DG, Myers, MG, Seeley, RJ, Schwartz, MW. Insulin activation of phosphatidylinositol 3-kinase in the hypothalamic arcuate nucleus: a key mediator of insulin-induced anorexia. Diabetes, 52(2), 227-31, 2003

Niswender, KD, Gallis, B, Blevins, JE, Corson, MA, Schwartz, MW, Baskin, DG. Immunocytochemical detection of phosphatidylinositol 3-kinase activation by insulin and leptin. J Histochem Cytochem, 51(3), 275-83, 2003

Niswender, KD, Schwartz, MW. Insulin and leptin revisited: adiposity signals with overlapping physiological and intracellular signaling capabilities. Front Neuroendocrinol, 24(1), 1-10, 2003

Morton, GJ, Niswender, KD, Rhodes, CJ, Myers, MG, Blevins, JE, Baskin, DG, Schwartz, MW. Arcuate nucleus-specific leptin receptor gene therapy attenuates the obesity phenotype of Koletsky (fa(k)/fa(k)) rats. Endocrinology, 144(5), 2016-24, 2003

Niswender, KD, Morton, GJ, Stearns, WH, Rhodes, CJ, Myers, MG, Schwartz, MW. Intracellular signalling. Key enzyme in leptin-induced anorexia. Nature, 413(6858), 794-5, 2001

Postic, C, Shiota, M, Niswender, KD, Jetton, TL, Chen, Y, Moates, JM, Shelton, KD, Lindner, J, Cherrington, AD, Magnuson, MA. Dual roles for glucokinase in glucose homeostasis as determined by liver and pancreatic beta cell-specific gene knock-outs using Cre recombinase. J Biol Chem, 274(1), 305-15, 1999

Kupershmidt, S, Yang, T, Anderson, ME, Wessels, A, Niswender, KD, Magnuson, MA, Roden, DM. Replacement by homologous recombination of the minK gene with lacZ reveals restriction of minK expression to the mouse cardiac conduction system. Circ Res, 84(2), 146-52, 1999

Lu, JT, Son, YJ, Lee, J, Jetton, TL, Shiota, M, Moscoso, L, Niswender, KD, Loewy, AD, Magnuson, MA, Sanes, JR, Emeson, RB. Mice lacking alpha-calcitonin gene-related peptide exhibit normal cardiovascular regulation and neuromuscular development. Mol Cell Neurosci, 14(2), 99-120, 1999

Evans, TJ, Miller, MA, Ganjam, VK, Niswender, KD, Ellersieck, MR, Krause, WJ, Youngquist, RS. Morphometric analysis of endometrial periglandular fibrosis in mares. Am J Vet Res, 59(10), 1209-14, 1998

Niswender, KD, Postic, C, Jetton, TL, Bennett, BD, Piston, DW, Efrat, S, Magnuson, MA. Cell-specific expression and regulation of a glucokinase gene locus transgene. J Biol Chem, 272(36), 22564-9, 1997

Ji, QS, Winnier, GE, Niswender, KD, Horstman, D, Wisdom, R, Magnuson, MA, Carpenter, G. Essential role of the tyrosine kinase substrate phospholipase C-gamma1 in mammalian growth and development. Proc Natl Acad Sci U S A, 94(7), 2999-3003, 1997

Niswender, KD, Postic, C, Shiota, M, Jetton, TL, Magnuson, MA. Effects of altered glucokinase gene copy number on blood glucose homoeostasis. Biochem Soc Trans, 25(1), 113-7, 1997

Niswender, KD, Shiota, M, Postic, C, Cherrington, AD, Magnuson, MA. Effects of increased glucokinase gene copy number on glucose homeostasis and hepatic glucose metabolism. J Biol Chem, 272(36), 22570-5, 1997

Niswender, KD, Li, J, Powell, MR, Loos, KR, Roberts, RM, Keisler, DH, Smith, MF. Effect of variants of interferon-tau with mutations near the carboxyl terminus on luteal life span in sheep. Biol Reprod, 56(1), 214-20, 1997

Qu, S, Niswender, KD, Ji, Q, van der Meer, R, Keeney, D, Magnuson, MA, Wisdom, R. Polydactyly and ectopic ZPA formation in Alx-4 mutant mice. Development, 124(20), 3999-4008, 1997

Postic, C, Niswender, KD, Decaux, JF, Parsa, R, Shelton, KD, Gouhot, B, Pettepher, CC, Granner, DK, Girard, J, Magnuson, MA. Cloning and characterization of the mouse glucokinase gene locus and identification of distal liver-specific DNase I hypersensitive sites. Genomics, 29(3), 740-50, 1995

Hawkins, DE, Niswender, KD, Oss, GM, Moeller, CL, Odde, KG, Sawyer, HR, Niswender, GD. An increase in serum lipids increases luteal lipid content and alters the disappearance rate of progesterone in cows. J Anim Sci, 73(2), 541-5, 1995

Niswender, KD, Blackman, SM, Rohde, L, Magnuson, MA, Piston, DW. Quantitative imaging of green fluorescent protein in cultured cells: comparison of microscopic techniques, use in fusion proteins and detection limits. J Microsc, 180 ( Pt 2), 109-16, 1995

Morita, H, Yano, Y, Niswender, KD, May, JM, Whitesell, RR, Wu, L, Printz, RL, Granner, DK, Magnuson, MA, Powers, AC. Coexpression of glucose transporters and glucokinase in Xenopus oocytes indicates that both glucose transport and phosphorylation determine glucose utilization. J Clin Invest, 94(4), 1373-82, 1994

Niswender, GD, McNatty, KP, Smith, P, Niswender, KD, Farin, CE, Sawyer, HR. Numbers of steroidogenic luteal cells in Booroola Merino ewes. J Reprod Fertil, 90(1), 185-90, 1990

Sawyer, HR, Niswender, KD, Braden, TD, Niswender, GD. Nuclear changes in ovine luteal cells in response to PGF2 alpha. Domest Anim Endocrinol, 7(2), 229-37, 1990