Division of Cardiovascular Medicine

Overview

Current research is focused on the role of oxidative stress in the development of diabetic heart failure after myocardial infarction.  Although it has been documented that an increased level of oxidative stress accompanies diabetes, little is know regarding oxidative stress associated with diabetic comorbid conditions such as myocardial infarction.  It has been shown that after MI, diabetes is associated with greater myocardial oxidative stress burden and concomitant worsening of residual ventricular function.

In addition, a second group of studies has identified a specific "Type 1diabetic" pattern of cardiac proteome changes indicative of diabetic cardiomyopathy presenting with higher oxidative stress, which may independently and cooperatively contribute to impaired cardiac function and heart failure in the diabetic heart subsequent to myocardial infarction.  Taken together, these studies suggest that analysis of isoprostane biosynthesis and protein expression profiles may be useful to predict the therapeutic response to established and novel antioxidant therapies for the prophylaxis of diabetic heart failure.

Selected Publications

• Smith, HM, Hamblin, M, Hill, MF. Greater propensity of diabetic myocardium for oxidative stress after myocardial infarction is associated with the development of heart failure. J Mol Cell Cardiol, 39(4), 657-65, 2005.
  

• Hill, M, Takano, H, Tang, XL, Kodani, E, Shirk, G, Bolli, R. Nitroglycerin induces late preconditioning against myocardial infarction in conscious rabbits despite development of nitrate tolerance. Circulation, 104(6), 694-9, 2001.

• Palace, VP, Hill, MF, Farahmand, F, Singal, PK. Mobilization of antioxidant vitamin pools and hemodynamic function after myocardial infarction. Circulation, 99(1), 121-6, 1999.

• Hill, MF, Singal, PK. Right and left myocardial antioxidant responses during heart failure subsequent to myocardial infarction. Circulation, 96(7), 2414-20, 1997.

• Hill, MF, Singal, PK. Antioxidant and oxidative stress changes during heart failure subsequent to myocardial infarction in rats. Am J Pathol, 148(1), 291-300, 1996.

• Kaul, N, Siveski-Iliskovic, N, Thomas, TP, Hill, M, Khaper, N, Singal, PK. Probucol improves antioxidant activity and modulates development of diabetic cardiomyopathy. Nutrition, 11(5 Suppl), 551-4, 1995.