Division of Cardiovascular Medicine

Hatzopoulos Lab

Overview

The Hatzopoulos lab focuses on Molecular and Cellular mechanisms of cardiac repair and regeneration, emphasizing the role of wnt and BMP signaling pathways in angiogenesis and fibrosis after ischemic injury.  We also explore the potential of induced pluripotent (iPS) cells to differentiate to cardiomyocytes as a future strategy for cardiac tissue regeneration.

Read more about the Hatzopoulos Lab . . .

Selected Publications:  

 
·         Aisagbonhi O., R. Meena, S. Ryzhov, N. Atria, I. Feoktistov, and A. K. Hatzopoulos. (2011). Experimental myocardial infarction triggers canonical Wnt signaling and endothelial-to-mesenchymal transition. Dis. Model Mech., 4: 469-483. (2011).
 
 
·          Rai M., J. M. Walthall, J. Hu and A.K. Hatzopoulos*.  Continuous antagonism by Dkk1 counter activates canonical wnt signaling and promotes cardiomyocyte differentiation of embryonic stem cells.  Stem Cells Dev.,  21: 54-66, 2012.
 
 
·          Perin E. C., J. T. Willerson, C. J. Pepine, T. D. Henry, S. G. Ellis, D. X. Zhao, G. V. Siva, D. Lai, J. D. Thomas, M. W. Kronenberg, A.D. Martin, R. D. Anderson, J.H. Traverse, M.S. Penn, S. Anwaruddin, A .K. Hatzopoulos, A.P. Gee, D.A. Taylor, C.R. Cogle, D. Smith, L. Westbrook, J. Chen, E. Handberg, R.E. Olson, C. Geither, S. Bowman, J. Francescon, S. Baraniuk, L. B. Piller, L. M. Simpson, C. Loghin, D. Aguilar, S. Richman, C. Zierold, J. Bettencourt, S. L. Sayre, R. W. Vojvodic, S.I. Skarlatos, D. J.Gordon, R.F. Ebert, M. Kwak, L. A. Moye', and R. D. Simari; for Cardiovascular Cell Therapy Research Network (CCTRN).  Effect of Transendocardial Delivery of Autologous Bone Marrow Mononuclear Cells on Functional Capacit, Left Ventricular Function, and Perfusion in Chronic Heart Failure:  The FOCUS-CCTRN Trial.  JAMA, 307: 1717-1726, 2012.
 
 
·          J. H. Traverse, T. D. Henry, C. J. Pepine, J. T. Willerson, D. X. Zhao, S. G. Ellis, J. R. Forder, R. D. Anderson, A. K. Hatzopoulos, M. S. Penn, E. C. Perin, J. Chambers, K. W. Baran, G. Raveendran, C. Lambert, A. Lerman, D. I. Simon, D. E. Vaughan, D. Lai, A. P. Gee, D. A. Taylor, C. R. Cogle, J. D. Thomas, R. E. Olson, S. Bowman, J. Francescon, C. Geither, E. Handberg, C. Kappenman, L. Westbrook, L. B. Piller, L. M. Simpson, S. Baraniuk, C. Loghin, D. Aguilar, S. Richman, C. Zierold, D. B. Spoon, J. Bettencourt, S. L. Sayre, R. W. Vojvodic, S. I. Skarlatos, D. J. Gordon, R. F. Ebert, M. Kwak, L. A. Moye', and R. D. Simari; for the Cardiovascular Cell Therapy Research Network (CCTRN).  Effect of the Use and Timing of Bone Marrow Mononuclear Cell Delivery on Left Ventricular Function After Acute Myocardial Infarction:  The TIME Randomized Trial.  JAMA,  6: 1-10, 2012.
 
 
·          Miller I. I., D. B. Melville, V. Tanwar, W. Rybski, A. Mukherjee, B. M. Shoemaker, W. D. Wang, J. A. Schoenhard, D. M. Roden, D. Darbar, E. W. Knapik and A. K. Hatzopoulos*.  Novel Atrial Fibrillation-associated gene GREMLIN2 regulates cardiac laterality, Cardiomyocyte differentiation and atrial rhythm.  Dis. Model Mech., in press.
 
 
·          SchulzH., R. Kolde, P. Adler, I. Aksoy, K. Anastassiadis, M. Bader, N. Billon, H. Boeuf, P.-Y. Bourillot, F. Buchholz, C. Dani, M. X. Doss, L. Forrester, R. Friel, M. Gitton, D. Henrique, J. Hescheler, H. Himmelbauer, N. Hubner, E. Karantzali, A. Kretsovali, S. Lubitz, M. Rai, L. Pradier, J. Reimand, A. Rolletschek, A. Sachinidis, P. Savatier, F. Stewart, M. P. Storm, M. Trouillas, J. Vilo, M. J. Welham, J. Winkler, A. Wobusand,  A. K. Hatzopoulos. (2009). The FunGenES database: a genomics resource for mouse Embryonic Stem cell differentiationPLoS One, 4: e6804.
 
 
·         Beck H., M. Semisch,C. Culmsee,N. Plesnila and A. K. Hatzopoulos. (2008). Egr-1 regulates expression of glial scar component phosphacan in astrocytes after experimental stroke. Am. J. of Pathology, 173: 77-92.
 
 
·          Kupatt C., J. Horstkotte, G. A. Vlastos, A. Pfosser, C. Lebherz, M. Semisch, M. Thalgott, K. Büttner, C. Browarzyk J. Mages,R. Hoffmann, A. Deten, M. Lamparter, F. Müller, H. Beck, H. Büning, P. Boekstegers and A. K. Hatzopoulos(2005). Embryonic endothelial progenitor cells expressing a broad range of pro-angiogenic and remodeling factors enhance vascularization and tissue recovery in acute and chronic ischemia. FASEB J., 19: 1576-1578.
 
 
·          WeiJ., S. Blum, M. Unger, G. Jarmy, M. Lamparter, A. Geishauser, G. A. Vlastos, G. Chan, K.-D. Fischer, D. Rattat, K.-M. Debatin, A. K. Hatzopoulos and C. Beltinger.  (2004). Embryonic endothelial progenitor cells armed with a suicide gene target hypoxic lung metastases after intravenous delivery. Cancer Cell, 5: 477-488.
 
 
·          Vajkoczy P., S. Blum, M. Lamparter, R. Mailhammer, R. Erber, B. Engelhardt, D. Vestweber and A. K. Hatzopoulos. (2003). Multistep nature of microvascular recruitment of ex vivo expanded embryonic endothelial progenitor cells during tumor angiogenesis. J. Exper. Med., 197: 1755-1765.
 
 

 

 

 
 

 

 

 

 
 

 

 

 

 
 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

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